Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
5ht6r_human | 26 | 1.32x32 | TM1 | S => GlnfsTer47 | frameshift | 4.232e-05 | 2 | 47254 | 0 | None | None | |
5ht6r_human | 91 | 23.49x49 | ECL1 | R => AlafsTer17 | frameshift | 8.337e-06 | 1 | 119954 | 0 | None | None | |
5ht6r_human | 151 | 4.50x50 | TM4 | W => Ter | stop gained | 8.418e-06 | 1 | 118794 | 0 | None | None | |
5ht6r_human | 310 | 7.43x42 | TM7 | Y => Ter | stop gained | 8.256e-06 | 1 | 121118 | 0 | None | None | |
5ht6r_human | 361 | C-term | R => ProfsTer5 | frameshift | 9.53e-06 | 1 | 104930 | 0 | None | None | ||
5ht6r_human | 367 | C-term | Q => Ter | stop gained | 1.187e-05 | 1 | 84230 | 0 | None | None | ||
5ht6r_human | 410 | C-term | L => AlafsTer67 | frameshift | 7.8e-05 | 4 | 51282 | 0 | None | None | ||
5ht6r_human | 429 | C-term | E => Ter | stop gained | 2.136e-05 | 2 | 93642 | 0 | None | None | ||
5ht6r_human | 3 | N-term | P => S | missense | 1.044e-05 | 1 | 95806 | 0 | nan | 0.478 | ||
5ht6r_human | 6 | N-term | G => R | missense | 1.186e-05 | 1 | 84314 | 0 | nan | 0.422 | ||
5ht6r_human | 8 | N-term | T => I | missense | 8.43e-05 | 8 | 94898 | 0 | nan | 0.0 | ||
5ht6r_human | 9 | N-term | A => S | missense | 2.112e-05 | 2 | 94708 | 0 | nan | 0.0 | ||
5ht6r_human | 15 | N-term | W => C | missense | 2.366e-05 | 2 | 84544 | 0 | 0.02 | 0.319 | ||
5ht6r_human | 16 | N-term | G => R | missense | 1.192e-05 | 1 | 83884 | 0 | nan | 0.34 | ||
5ht6r_human | 16 | N-term | G => E | missense | 1.229e-05 | 1 | 81338 | 0 | nan | 0.007 | ||
5ht6r_human | 16 | N-term | G => V | missense | 1.229e-05 | 1 | 81338 | 0 | nan | 0.255 | ||
5ht6r_human | 17 | N-term | A => T | missense | 1.247e-05 | 1 | 80202 | 0 | 0.48 | 0.01 | ||
5ht6r_human | 18 | N-term | G => R | missense | 0.00141 | 109 | 77300 | 0 | 0.16 | 0.011 | ||
5ht6r_human | 19 | N-term | P => L | missense | 4.305e-05 | 3 | 69680 | 0 | 0.16 | 0.001 | ||
5ht6r_human | 24 | N-term | G => V | missense | 9.722e-05 | 5 | 51428 | 0 | 0.3 | 0.17 | ||
5ht6r_human | 27 | 1.33x33 | TM1 | G => C | missense | 2.521e-05 | 1 | 39668 | 0 | 0.04 | 0.884 | |
5ht6r_human | 29 | 1.35x35 | TM1 | V => G | missense | 5.179e-05 | 2 | 38620 | 0 | 0.02 | 0.991 | |
5ht6r_human | 29 | 1.35x35 | TM1 | V => A | missense | 2.589e-05 | 1 | 38620 | 0 | 0.0 | 0.97 | |
5ht6r_human | 30 | 1.36x36 | TM1 | A => E | missense | 2.565e-05 | 1 | 38986 | 0 | 0.0 | 0.997 | |
5ht6r_human | 34 | 1.40x40 | TM1 | C => S | missense | 2.281e-05 | 1 | 43842 | 0 | 0.47 | 0.074 | |
5ht6r_human | 34 | 1.40x40 | TM1 | C => Y | missense | 2.267e-05 | 1 | 44106 | 0 | 0.0 | 0.791 | |
5ht6r_human | 36 | 1.42x42 | TM1 | V => A | missense | 6.484e-05 | 3 | 46266 | 0 | 0.0 | 0.55 | |
5ht6r_human | 43 | 1.49x49 | TM1 | A => V | missense | 8.762e-05 | 6 | 68480 | 0 | 0.0 | 0.909 | |
5ht6r_human | 45 | 1.51x51 | TM1 | S => A | missense | 1.355e-05 | 1 | 73798 | 0 | 0.57 | 0.005 | |
5ht6r_human | 45 | 1.51x51 | TM1 | S => P | missense | 1.355e-05 | 1 | 73798 | 0 | 0.22 | 0.319 | |
5ht6r_human | 45 | 1.51x51 | TM1 | S => T | missense | 1.355e-05 | 1 | 73798 | 0 | 0.78 | 0.005 | |
5ht6r_human | 45 | 1.51x51 | TM1 | S => W | missense | 0.001153 | 86 | 74620 | 0 | 0.18 | 0.856 | |
5ht6r_human | 46 | 1.52x52 | TM1 | L => P | missense | 1.268e-05 | 1 | 78872 | 0 | 0.0 | 1.0 | |
5ht6r_human | 47 | 1.53x53 | TM1 | L => P | missense | 0.0001207 | 10 | 82852 | 0 | 0.0 | 0.997 | |
5ht6r_human | 48 | 1.54x54 | TM1 | I => M | missense | 2.307e-05 | 2 | 86706 | 0 | 0.02 | 0.991 | |
5ht6r_human | 49 | 1.55x55 | TM1 | A => V | missense | 1.124e-05 | 1 | 88962 | 0 | 1.0 | 0.013 | |
5ht6r_human | 53 | 1.59x59 | TM1 | T => A | missense | 9.987e-06 | 1 | 100126 | 0 | 0.28 | 0.012 | |
5ht6r_human | 55 | 12.48x48 | ICL1 | P => T | missense | 1.93e-05 | 2 | 103650 | 0 | 0.02 | 0.155 | |
5ht6r_human | 62 | 2.40x40 | TM2 | N => S | missense | 1.742e-05 | 2 | 114784 | 0 | 0.0 | 0.954 | |
5ht6r_human | 64 | 2.42x42 | TM2 | F => L | missense | 8.637e-06 | 1 | 115778 | 0 | 0.0 | 1.0 | |
5ht6r_human | 67 | 2.45x45 | TM2 | S => P | missense | 8.533e-06 | 1 | 117190 | 0 | 0.0 | 1.0 | |
5ht6r_human | 69 | 2.47x47 | TM2 | F => L | missense | 8.467e-06 | 1 | 118106 | 0 | 0.13 | 0.306 | |
5ht6r_human | 79 | 2.57x56 | TM2 | V => M | missense | 8.381e-06 | 1 | 119312 | 0 | 0.0 | 0.999 | |
5ht6r_human | 87 | 2.65x64 | TM2 | A => V | missense | 9.18e-05 | 11 | 119826 | 0 | 0.35 | 0.002 | |
5ht6r_human | 87 | 2.65x64 | TM2 | A => G | missense | 8.345e-06 | 1 | 119826 | 0 | 0.24 | 0.362 | |
5ht6r_human | 89 | 2.67x66 | TM2 | Y => H | missense | 5.838e-05 | 7 | 119908 | 0 | 0.25 | 0.994 | |
5ht6r_human | 89 | 2.67x66 | TM2 | Y => C | missense | 0.0002335 | 28 | 119920 | 0 | 0.2 | 0.518 | |
5ht6r_human | 90 | 2.68x67 | TM2 | G => R | missense | 8.332e-06 | 1 | 120016 | 0 | 0.04 | 0.979 | |
5ht6r_human | 91 | 23.49x49 | ECL1 | R => C | missense | 8.333e-06 | 1 | 120008 | 0 | 0.17 | 0.935 | |
5ht6r_human | 96 | 3.22x22 | TM3 | R => C | missense | 8.342e-06 | 1 | 119874 | 0 | 0.08 | 0.846 | |
5ht6r_human | 103 | 3.29x29 | TM3 | T => P | missense | 8.328e-06 | 1 | 120082 | 0 | 0.06 | 0.167 | |
5ht6r_human | 109 | 3.35x35 | TM3 | C => W | missense | 8.31e-06 | 1 | 120344 | 0 | 0.0 | 0.995 | |
5ht6r_human | 110 | 3.36x36 | TM3 | C => W | missense | 1.662e-05 | 2 | 120348 | 0 | 0.0 | 0.999 | LB (hydrophobic, polar (hydrogen bond)) |
5ht6r_human | 112 | 3.38x38 | TM3 | A => T | missense | 1.661e-05 | 2 | 120380 | 0 | 0.0 | 1.0 | |
5ht6r_human | 115 | 3.41x41 | TM3 | L => F | missense | 1.661e-05 | 2 | 120436 | 0 | 0.0 | 0.999 | |
5ht6r_human | 118 | 3.44x44 | TM3 | C => Y | missense | 4.981e-05 | 6 | 120446 | 0 | 0.0 | 1.0 | |
5ht6r_human | 120 | 3.46x46 | TM3 | I => L | missense | 8.302e-06 | 1 | 120458 | 0 | 0.0 | 0.999 | |
5ht6r_human | 121 | 3.47x47 | TM3 | S => N | missense | 8.302e-06 | 1 | 120448 | 0 | 0.0 | 1.0 | |
5ht6r_human | 126 | 3.52x52 | TM3 | L => Q | missense | 1.661e-05 | 2 | 120406 | 0 | 0.0 | 0.997 | |
5ht6r_human | 136 | 34.55x55 | ICL2 | L => R | missense | 8.328e-06 | 1 | 120084 | 0 | 1.0 | 0.349 | GP (contact) |
5ht6r_human | 138 | 34.57x57 | ICL2 | M => L | missense | 2.5e-05 | 3 | 120018 | 0 | 0.0 | 0.926 | GP (contact) |
5ht6r_human | 138 | 34.57x57 | ICL2 | M => K | missense | 8.335e-06 | 1 | 119980 | 0 | 0.02 | 0.401 | GP (contact) |
5ht6r_human | 143 | 4.42x42 | TM4 | A => S | missense | 7.519e-05 | 9 | 119700 | 0 | 0.0 | 0.999 | |
5ht6r_human | 145 | 4.44x44 | TM4 | A => S | missense | 8.36e-06 | 1 | 119616 | 0 | 0.07 | 0.297 | |
5ht6r_human | 154 | 4.53x53 | TM4 | A => T | missense | 8.442e-06 | 1 | 118462 | 0 | 0.0 | 0.995 | |
5ht6r_human | 168 | ECL2 | E => K | missense | 4.252e-05 | 5 | 117602 | 0 | 0.55 | 0.013 | ||
5ht6r_human | 172 | ECL2 | A => T | missense | 8.506e-06 | 1 | 117558 | 0 | 0.45 | 0.003 | ||
5ht6r_human | 173 | ECL2 | R => W | missense | 4.253e-05 | 5 | 117556 | 0 | 0.02 | 0.773 | ||
5ht6r_human | 173 | ECL2 | R => Q | missense | 8.503e-06 | 1 | 117608 | 0 | 0.78 | 0.009 | ||
5ht6r_human | 173 | ECL2 | R => P | missense | 8.503e-06 | 1 | 117608 | 0 | 0.28 | 0.007 | ||
5ht6r_human | 174 | ECL2 | P => S | missense | 8.502e-06 | 1 | 117618 | 0 | 0.83 | 0.006 | ||
5ht6r_human | 181 | 45.51x51 | ECL2 | R => G | missense | 8.454e-06 | 1 | 118286 | 0 | 0.12 | 0.609 | |
5ht6r_human | 183 | ECL2 | L => R | missense | 8.434e-06 | 1 | 118570 | 0 | 0.67 | 0.058 | ||
5ht6r_human | 190 | 5.40x41 | TM5 | L => F | missense | 8.376e-06 | 1 | 119386 | 0 | 0.0 | 1.0 | |
5ht6r_human | 193 | 5.43x44 | TM5 | S => L | missense | 8.363e-06 | 1 | 119576 | 0 | 0.0 | 0.995 | |
5ht6r_human | 202 | 5.52x52 | TM5 | G => D | missense | 8.351e-06 | 1 | 119748 | 0 | 0.01 | 0.817 | |
5ht6r_human | 202 | 5.52x52 | TM5 | G => V | missense | 3.34e-05 | 4 | 119748 | 0 | 0.19 | 0.058 | |
5ht6r_human | 204 | 5.54x54 | TM5 | I => V | missense | 8.355e-06 | 1 | 119684 | 0 | 0.02 | 0.972 | |
5ht6r_human | 209 | 5.59x59 | TM5 | C => Y | missense | 1.679e-05 | 2 | 119134 | 0 | 0.0 | 0.721 | |
5ht6r_human | 216 | 5.66x66 | TM5 | R => S | missense | 8.503e-06 | 1 | 117604 | 0 | 0.02 | 0.993 | GP (contact) |
5ht6r_human | 216 | 5.66x66 | TM5 | R => C | missense | 8.503e-06 | 1 | 117604 | 0 | 0.0 | 0.997 | GP (contact) |
5ht6r_human | 220 | 5.70x70 | TM5 | V => M | missense | 4.342e-05 | 5 | 115142 | 0 | 0.13 | 0.164 | |
5ht6r_human | 221 | 5.71x71 | TM5 | Q => K | missense | 0.0002103 | 24 | 114098 | 1 | 0.09 | 0.593 | GP (contact) |
5ht6r_human | 226 | 5.76x76 | TM5 | T => P | missense | 9.391e-06 | 1 | 106482 | 0 | 0.23 | 0.001 | |
5ht6r_human | 227 | ICL3 | T => A | missense | 2.878e-05 | 3 | 104238 | 0 | 0.59 | 0.004 | ||
5ht6r_human | 227 | ICL3 | T => N | missense | 9.669e-06 | 1 | 103422 | 0 | 0.21 | 0.219 | ||
5ht6r_human | 228 | ICL3 | G => S | missense | 9.826e-06 | 1 | 101766 | 0 | 0.29 | 0.108 | ||
5ht6r_human | 230 | ICL3 | A => V | missense | 1.034e-05 | 1 | 96690 | 0 | 0.13 | 0.297 | ||
5ht6r_human | 231 | ICL3 | S => T | missense | 1.068e-05 | 1 | 93618 | 0 | 0.7 | 0.004 | ||
5ht6r_human | 243 | ICL3 | P => L | missense | 8.26e-06 | 1 | 121072 | 0 | 0.12 | 0.426 | ||
5ht6r_human | 244 | ICL3 | R => C | missense | 0.0001074 | 13 | 121076 | 0 | 0.24 | 0.009 | ||
5ht6r_human | 244 | ICL3 | R => H | missense | 8.259e-06 | 1 | 121074 | 0 | 0.64 | 0.009 | ||
5ht6r_human | 245 | ICL3 | P => S | missense | 2.477e-05 | 3 | 121090 | 0 | 0.47 | 0.014 | ||
5ht6r_human | 245 | ICL3 | P => T | missense | 8.258e-06 | 1 | 121090 | 0 | 0.32 | 0.008 | ||
5ht6r_human | 245 | ICL3 | P => R | missense | 2.477e-05 | 3 | 121110 | 0 | 0.27 | 0.281 | ||
5ht6r_human | 248 | ICL3 | E => K | missense | 8.252e-06 | 1 | 121190 | 0 | 0.55 | 0.032 | ||
5ht6r_human | 254 | ICL3 | R => H | missense | 5.778e-05 | 7 | 121146 | 0 | 0.01 | 0.954 | ||
5ht6r_human | 255 | ICL3 | L => P | missense | 8.254e-06 | 1 | 121156 | 0 | 0.02 | 0.974 | ||
5ht6r_human | 257 | 6.24x24 | TM6 | T => M | missense | 1.651e-05 | 2 | 121148 | 0 | 0.23 | 0.029 | |
5ht6r_human | 259 | 6.26x26 | TM6 | H => N | missense | 1.651e-05 | 2 | 121146 | 0 | 0.04 | 0.348 | GP (contact) |
5ht6r_human | 261 | 6.28x28 | TM6 | R => S | missense | 8.26e-06 | 1 | 121072 | 0 | 0.2 | 0.069 | GP (contact) |
5ht6r_human | 269 | 6.36x36 | TM6 | T => M | missense | 5.788e-05 | 7 | 120934 | 0 | 0.0 | 0.999 | GP (contact) |
5ht6r_human | 284 | 6.51x51 | TM6 | F => S | missense | 1.666e-05 | 2 | 120060 | 0 | 0.0 | 0.995 | LB (hydrophobic, Van der Waals) |
5ht6r_human | 284 | 6.51x51 | TM6 | F => Y | missense | 1.666e-05 | 2 | 120060 | 0 | 0.05 | 0.934 | LB (hydrophobic, Van der Waals) |
5ht6r_human | 288 | 6.55x55 | TM6 | N => Y | missense | 8.382e-06 | 1 | 119304 | 0 | 0.0 | 0.979 | LB (polar (hydrogen bond), Van der Waals) |
5ht6r_human | 290 | 6.57x57 | TM6 | V => L | missense | 8.415e-06 | 1 | 118832 | 0 | 0.28 | 0.016 | |
5ht6r_human | 292 | 6.59x59 | TM6 | A => T | missense | 1.765e-05 | 2 | 113326 | 0 | 0.02 | 0.954 | |
5ht6r_human | 293 | 6.60x60 | TM6 | V => M | missense | 7.015e-05 | 8 | 114046 | 0 | 0.04 | 0.997 | |
5ht6r_human | 295 | ECL3 | D => N | missense | 8.668e-06 | 1 | 115370 | 0 | 0.04 | 0.009 | ||
5ht6r_human | 295 | ECL3 | D => H | missense | 8.668e-06 | 1 | 115370 | 0 | 0.01 | 0.676 | ||
5ht6r_human | 296 | ECL3 | C => R | missense | 1.722e-05 | 2 | 116116 | 0 | 0.0 | 0.874 | ||
5ht6r_human | 298 | 7.31x30 | TM7 | S => F | missense | 1.702e-05 | 2 | 117496 | 0 | 0.0 | 0.797 | |
5ht6r_human | 299 | 7.32x31 | TM7 | P => S | missense | 8.48e-06 | 1 | 117920 | 0 | 0.45 | 0.155 | |
5ht6r_human | 303 | 7.36x35 | TM7 | D => N | missense | 1.665e-05 | 2 | 120106 | 0 | 0.13 | 0.85 | |
5ht6r_human | 303 | 7.36x35 | TM7 | D => E | missense | 1.662e-05 | 2 | 120310 | 0 | 0.07 | 0.758 | |
5ht6r_human | 307 | 7.40x39 | TM7 | W => R | missense | 3.309e-05 | 4 | 120894 | 0 | 0.0 | 1.0 | |
5ht6r_human | 309 | 7.42x41 | TM7 | G => C | missense | 9.089e-05 | 11 | 121026 | 0 | 0.0 | 1.0 | |
5ht6r_human | 309 | 7.42x41 | TM7 | G => V | missense | 8.262e-06 | 1 | 121040 | 0 | 0.0 | 1.0 | |
5ht6r_human | 311 | 7.44x43 | TM7 | C => R | missense | 1.651e-05 | 2 | 121136 | 0 | 0.0 | 0.993 | SodiumPocket MicroSwitch |
5ht6r_human | 314 | 7.47x47 | TM7 | T => A | missense | 8.25e-06 | 1 | 121214 | 0 | 0.05 | 0.627 | |
5ht6r_human | 314 | 7.47x47 | TM7 | T => I | missense | 7.425e-05 | 9 | 121218 | 0 | 0.0 | 0.972 | |
5ht6r_human | 315 | 7.48x48 | TM7 | M => R | missense | 1.65e-05 | 2 | 121242 | 0 | 0.0 | 0.866 | |
5ht6r_human | 320 | 7.53x53 | TM7 | Y => H | missense | 8.244e-06 | 1 | 121296 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
5ht6r_human | 322 | 7.55x55 | TM7 | L => P | missense | 8.244e-06 | 1 | 121294 | 0 | 0.0 | 0.993 | GP (contact) |
5ht6r_human | 324 | 8.47x47 | H8 | M => K | missense | 8.246e-06 | 1 | 121268 | 0 | 0.04 | 0.96 | GP (contact) |
5ht6r_human | 325 | 8.48x48 | H8 | R => W | missense | 2.474e-05 | 3 | 121244 | 0 | 0.0 | 0.955 | GP (contact) |
5ht6r_human | 325 | 8.48x48 | H8 | R => Q | missense | 8.249e-06 | 1 | 121228 | 0 | 0.1 | 0.087 | GP (contact) |
5ht6r_human | 329 | 8.52x52 | H8 | R => W | missense | 8.259e-06 | 1 | 121086 | 0 | 0.0 | 0.991 | |
5ht6r_human | 329 | 8.52x52 | H8 | R => Q | missense | 8.261e-06 | 1 | 121056 | 0 | 0.04 | 0.532 | |
5ht6r_human | 330 | 8.53x53 | H8 | A => V | missense | 4.957e-05 | 6 | 121048 | 0 | 0.12 | 0.759 | |
5ht6r_human | 332 | 8.55x55 | H8 | G => A | missense | 1.654e-05 | 2 | 120922 | 0 | 0.46 | 0.002 | |
5ht6r_human | 336 | 8.59x59 | H8 | P => R | missense | 8.283e-06 | 1 | 120730 | 0 | 0.04 | 0.686 | |
5ht6r_human | 337 | 8.60x60 | H8 | C => R | missense | 8.294e-06 | 1 | 120570 | 0 | 0.0 | 0.997 | |
5ht6r_human | 339 | C-term | R => S | missense | 3.321e-05 | 4 | 120432 | 0 | 0.03 | 0.023 | ||
5ht6r_human | 339 | C-term | R => C | missense | 8.303e-06 | 1 | 120432 | 0 | 0.04 | 0.01 | ||
5ht6r_human | 341 | C-term | P => L | missense | 1.664e-05 | 2 | 120166 | 0 | 0.06 | 0.002 | ||
5ht6r_human | 342 | C-term | R => W | missense | 3.331e-05 | 4 | 120096 | 0 | 0.24 | 0.0 | ||
5ht6r_human | 342 | C-term | R => Q | missense | 4.999e-05 | 6 | 120022 | 0 | 0.44 | 0.001 | ||
5ht6r_human | 342 | C-term | R => L | missense | 3.333e-05 | 4 | 120022 | 0 | 0.7 | 0.024 | ||
5ht6r_human | 344 | C-term | R => C | missense | 1.668e-05 | 2 | 119906 | 0 | 0.06 | 0.386 | ||
5ht6r_human | 350 | C-term | S => L | missense | 7.622e-05 | 9 | 118082 | 0 | 0.0 | 0.274 | ||
5ht6r_human | 351 | C-term | P => L | missense | 8.513e-06 | 1 | 117466 | 0 | 0.71 | 0.002 | ||
5ht6r_human | 354 | C-term | R => C | missense | 8.6e-06 | 1 | 116282 | 0 | 0.01 | 0.77 | ||
5ht6r_human | 355 | C-term | T => I | missense | 1.762e-05 | 2 | 113526 | 0 | 0.09 | 0.303 | ||
5ht6r_human | 361 | C-term | R => W | missense | 0.00102 | 104 | 101982 | 1 | 0.0 | 0.999 | ||
5ht6r_human | 361 | C-term | R => Q | missense | 1.98e-05 | 2 | 100990 | 0 | 0.04 | 0.983 | ||
5ht6r_human | 364 | C-term | L => I | missense | 1.067e-05 | 1 | 93716 | 0 | 0.37 | 0.166 | ||
5ht6r_human | 365 | C-term | S => R | missense | 1.12e-05 | 1 | 89314 | 0 | 0.0 | 0.584 | ||
5ht6r_human | 367 | C-term | Q => R | missense | 1.207e-05 | 1 | 82868 | 0 | 0.3 | 0.007 | ||
5ht6r_human | 371 | C-term | P => L | missense | 1.481e-05 | 1 | 67526 | 0 | 0.12 | 0.085 | ||
5ht6r_human | 375 | C-term | P => T | missense | 0.002774 | 157 | 56606 | 0 | 0.29 | 0.054 | ||
5ht6r_human | 375 | C-term | P => L | missense | 1.779e-05 | 1 | 56226 | 0 | 0.23 | 0.002 | ||
5ht6r_human | 376 | C-term | P => S | missense | 1.84e-05 | 1 | 54340 | 0 | 0.27 | 0.002 | ||
5ht6r_human | 376 | C-term | P => L | missense | 3.73e-05 | 2 | 53620 | 0 | 0.26 | 0.001 | ||
5ht6r_human | 377 | C-term | D => H | missense | 1.906e-05 | 1 | 52468 | 0 | 0.04 | 0.006 | ||
5ht6r_human | 380 | C-term | S => L | missense | 0.0001323 | 6 | 45346 | 0 | 0.23 | 0.002 | ||
5ht6r_human | 384 | C-term | A => T | missense | 2.648e-05 | 1 | 37768 | 0 | nan | 0.002 | ||
5ht6r_human | 384 | C-term | A => S | missense | 5.295e-05 | 2 | 37768 | 0 | nan | 0.0 | ||
5ht6r_human | 384 | C-term | A => V | missense | 0.001309 | 50 | 38192 | 0 | nan | 0.002 | ||
5ht6r_human | 388 | C-term | G => S | missense | 9.735e-05 | 3 | 30816 | 0 | 0.75 | 0.005 | ||
5ht6r_human | 388 | C-term | G => C | missense | 3.245e-05 | 1 | 30816 | 0 | 0.05 | 0.013 | ||
5ht6r_human | 390 | C-term | S => A | missense | 3.344e-05 | 1 | 29906 | 0 | 0.18 | 0.007 | ||
5ht6r_human | 393 | C-term | R => L | missense | 0.0001694 | 5 | 29508 | 0 | 0.37 | 0.0 | ||
5ht6r_human | 395 | C-term | T => M | missense | 0.0001692 | 5 | 29544 | 0 | 0.06 | 0.012 | ||
5ht6r_human | 395 | C-term | T => K | missense | 3.385e-05 | 1 | 29544 | 0 | 0.38 | 0.034 | ||
5ht6r_human | 400 | C-term | L => P | missense | 2.932e-05 | 1 | 34106 | 0 | 0.05 | 0.183 | ||
5ht6r_human | 402 | C-term | G => D | missense | 2.751e-05 | 1 | 36356 | 0 | 0.14 | 0.101 | ||
5ht6r_human | 404 | C-term | A => T | missense | 2.407e-05 | 1 | 41540 | 0 | 0.21 | 0.002 | ||
5ht6r_human | 407 | C-term | D => G | missense | 1.95e-05 | 1 | 51282 | 0 | nan | 0.002 | ||
5ht6r_human | 407 | C-term | D => E | missense | 1.884e-05 | 1 | 53078 | 0 | nan | 0.002 | ||
5ht6r_human | 408 | C-term | P => S | missense | 1.832e-05 | 1 | 54596 | 0 | nan | 0.002 | ||
5ht6r_human | 411 | C-term | P => S | missense | 1.508e-05 | 1 | 66328 | 0 | nan | 0.019 | ||
5ht6r_human | 414 | C-term | A => T | missense | 1.366e-05 | 1 | 73192 | 0 | nan | 0.001 | ||
5ht6r_human | 415 | C-term | A => T | missense | 1.31e-05 | 1 | 76346 | 0 | nan | 0.004 | ||
5ht6r_human | 417 | C-term | A => T | missense | 7.188e-05 | 6 | 83474 | 0 | nan | 0.0 | ||
5ht6r_human | 417 | C-term | A => V | missense | 1.181e-05 | 1 | 84702 | 0 | 1.0 | 0.0 | ||
5ht6r_human | 418 | C-term | V => I | missense | 6.848e-05 | 6 | 87616 | 0 | nan | 0.012 | ||
5ht6r_human | 420 | C-term | F => C | missense | 1.085e-05 | 1 | 92154 | 0 | nan | 0.002 | ||
5ht6r_human | 423 | C-term | I => V | missense | 3.201e-05 | 3 | 93720 | 0 | nan | 0.0 | ||
5ht6r_human | 424 | C-term | D => N | missense | 2.134e-05 | 2 | 93714 | 0 | nan | 0.004 | ||
5ht6r_human | 426 | C-term | A => T | missense | 1.061e-05 | 1 | 94258 | 0 | nan | 0.001 | ||
5ht6r_human | 426 | C-term | A => V | missense | 5.302e-05 | 5 | 94302 | 0 | 1.0 | 0.001 | ||
5ht6r_human | 428 | C-term | P => H | missense | 1.066e-05 | 1 | 93816 | 0 | nan | 0.417 | ||
5ht6r_human | 429 | C-term | E => K | missense | 9.611e-05 | 9 | 93642 | 0 | nan | 0.006 | ||
5ht6r_human | 431 | C-term | R => W | missense | 3.246e-05 | 3 | 92426 | 0 | nan | 0.632 | ||
5ht6r_human | 431 | C-term | R => Q | missense | 4.316e-05 | 4 | 92688 | 0 | nan | 0.002 | ||
5ht6r_human | 431 | C-term | R => L | missense | 1.079e-05 | 1 | 92688 | 0 | nan | 0.14 | ||
5ht6r_human | 432 | C-term | P => L | missense | 2.171e-05 | 2 | 92122 | 0 | 1.0 | 0.0 | ||
5ht6r_human | 433 | C-term | H => Y | missense | 7.624e-05 | 7 | 91812 | 0 | nan | 0.261 | ||
5ht6r_human | 434 | C-term | P => L | missense | 0.0002646 | 24 | 90692 | 0 | nan | 0.002 | ||
5ht6r_human | 439 | C-term | T => M | missense | 0.0004897 | 39 | 79646 | 0 | nan | 0.005 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue